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Technical Leader - Pre-Formulation and Formulation - Yorkshire

Scientific and Drug Discovery - Other
Ref: 1002 Date Posted: Wednesday 13 Jun 2018
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Technical Leader – Pre-Formulation and Formulation

Entrust are currently supporting an impressive, growing science led business who are focused on delivering a comprehensive platform of services to clients requiring innovative science-based solutions.

The role is offered on a full time permanent basis and is based on their site in West Yorkshire.

The Technical Leader – Pre-Formulation and Formulation will lead drug development projects from materials characterisation, solid form optimisation and compatibility screening, through to formulation for pre-clinical and First in Human studies. 

The role will involve experimental design and data interpretation from a diverse range of solid state and related techniques to optimise pre-formulation strategies – e.g. XRD, particle size, surface area / porosity, thermal, DVS, isothermal calorimetry, micronizing and milling techniques, freeze drying, spray drying, blending approaches hot stage and polarised light microscopy – in support of studies including but not limited to

General Responsibilities:

  • Revenue generating laboratory-based pre-formulation and formulation project work, applying diverse techniques to a wide range of sample types and technical challenges. May act as Lead Scientist or Project Manager, as required.
  • Manage client programmes focussing on pre-formulation, formulation and materials characterisation.
  • Liaise with colleague’s including operational teams to resource such programmes.
  • Associated data interpretation and report writing; peer review of data / reports generated by colleagues.
  • Train and mentor colleagues in own specialist techniques, processes, instruments, providing user support, method and instrument troubleshooting and technical guidance.
  • Within specialist area, advising commercial colleagues on the most appropriate solution to customer problems, including solutions not currently offered by the organisation (but may be offered within the Group or could be offered through capital expenditure). Will contribute to, and review, discipline-related quotes when required to do so.
  • Within specialist area, liaise and consult with appropriate colleagues within the Group to facilitate meeting a, customer requirement or provide technical / instrumentation support and back up.
  • Method development and validation, including drafting of related documents (methods, protocols, reports).
  • Client liaison, inter-group liaison, internal projects and initiatives.
  • Contributing to and adhering to company standard operating procedures.

About You:

  • PhD in Pharmaceutics, Organic Chemistry, Pharmaceutical Science or related scientific field with demonstrated, relevant experience.
  • Wide-ranging experience in the pharmaceutical industry in small molecule pre-formulation and formulation drug development across a range of delivery routes (oral, parenteral, inhalation etc.) and therapeutic indications.
  • Experienced in interpreting data to provide formulation strategies to maximise bioavailability and exposure of poorly soluble drugs for pre-clinical and First in Human studies.
  • Experienced in applying complex analytical instrumentation for physical-chemical characterisation of drug substances, excipients and formulations.
  • Experience of working in a regulated environment (quality, health and safety).
  • Familiarity with the drug development regulatory pathway (e.g. IND, CMC requirements)
  • Demonstrated ability to take initiative, think and work independently, problem-solve, work in teams and multitask.
  • Able to identify and highlight own training needs, and proactively upskill.

My client offers:

  • A great working environment
  • Great Career Progression
  • Market Leading Staff Salary
  • Outstanding Company Benefits  

If you are interested in discussing things further then please contact me on 01224 608988 or email suzi@entrustpeople.co.uk

Entrust People are a specialist European life sciences resourcing partner who is dedicated to finding the best talent in the niche disciplines which our business supports